自发睡眠与诱发觉醒。一项深度脑电图研究。

Spontaneous sleep and induced arousal. A depth-electroencephalographic study.

作者信息

Westmoreland B F, Groover R V, Klass D W

出版信息

J Neurol Sci. 1976 Jul;28(3):353-60. doi: 10.1016/0022-510x(76)90029-0.

Abstract

Although arousal effects from electric stimulation have been found in animals, reports of similar responses in humans have been uncommon. During depth electroencephalography in a 16-year-old boy for evaluation of intractable temporal lobe seizures, electric stimulation of a pair of contact leads located within the dorsal and medial portions of the thalamus but not within specific sensory nuclei produced unequivocal behavioral and electrographic arousals from spontaneous sleep. Lowvoltage stimuli were effective during non-REM and REM sleep. These findings verify the presence of a thalamic arousal system in the human.

摘要

尽管在动物身上发现了电刺激引起的唤醒效应，但关于人类有类似反应的报道却并不常见。在一名16岁男孩进行深度脑电图检查以评估难治性颞叶癫痫期间，对位于丘脑背侧和内侧部分但不在特定感觉核内的一对接触电极进行电刺激，引发了从自发睡眠中明确的行为和脑电图唤醒。低电压刺激在非快速眼动睡眠和快速眼动睡眠期间均有效。这些发现证实了人类丘脑唤醒系统的存在。