Aperia A, Eklöf A C, Holtbäck U, Nowicki S, Sundelöf M, Greengard P
Department of Woman and Child Health, St. Göran's Children's Hospital, Karolinska Institute, Stockholm, Sweden.
Adv Pharmacol. 1998;42:870-3. doi: 10.1016/s1054-3589(08)60885-6.
Intrarenally formed dopamine induced natriuresis by inhibiting the activity of renal tubular Na/KATPase. This effect is mediated via a complex signal network, which includes inhibition of PP1 via the adenylyl cyclase-PKA-DARPP32 pathway and activation of PKC via the PLA2-arachidonic acid-20HETE pathway. The renal dopamine availability is a major determinant of the natriuretic effect of dopamine and is to a large extent modulated by the activity of COMT. The possibility that regulation of dopamine storage and release influences renal dopamine effects should be considered.
肾内生成的多巴胺通过抑制肾小管钠钾ATP酶的活性诱导利钠作用。这种效应是通过一个复杂的信号网络介导的，该网络包括通过腺苷酸环化酶 - PKA - DARPP32途径抑制PP1以及通过PLA2 - 花生四烯酸 - 20HETE途径激活PKC。肾脏多巴胺的可用性是多巴胺利钠作用的主要决定因素，并且在很大程度上受儿茶酚 - O - 甲基转移酶（COMT）活性的调节。应该考虑多巴胺储存和释放的调节影响肾脏多巴胺效应的可能性。
