Korolkiewicz R, Sliwinski W, Rekowski P, Halama A, Szczurowicz A, Korolkiewicz K Z
Department of Pharmacology, Medical University of Gdansk, Poland.
Acta Physiol Hung. 1996;84(4):429-31.
Tachyphylaxis to SP decreased the effect of M15 and Gal(1-14)-[Abu8]SCY-I on gastric smooth muscles, without effect on the action of Gal. These findings support our initial hypothesis: the action of M15 and Gal(1-14)-[Abu8]SCY-I on the smooth muscles may not only be due to their agonist activity at Gal receptors, but may result from a subsequent stimulation of receptors for SP and perhaps for other tachykinins as well, however, a possibility that Gal analogues release endogenous SP can not be excluded. Further studies involving a tachykinin antagonist (spantide) are in progress at the moment. [1].
对速激肽的快速耐受性降低了M15和Gal(1-14)-[Abu8]SCY-I对胃平滑肌的作用，但对Gal的作用无影响。这些发现支持了我们最初的假设：M15和Gal(1-14)-[Abu8]SCY-I对平滑肌的作用可能不仅归因于它们对Gal受体的激动剂活性，还可能源于随后对速激肽受体（可能还有其他速激肽受体）的刺激，然而，不能排除Gal类似物释放内源性速激肽的可能性。目前正在进行涉及速激肽拮抗剂（spantide）的进一步研究。[1]
