Plaznik A, Stefański R, Jessa M, Nazar M, Bidziński A
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland.
Acta Physiol Hung. 1996;84(4):449-51.
The results clearly indicate that the hippocampus, rather than nucleus accumbens is involved in mediating anxiolytic-like effects of the 5-HT1A receptor agonists. Furthermore, hippocampal postsynaptic 5-HT1A receptors may account for the anti-emotional influence of this groups of drugs. As far as the 5-HT3 receptor antagonists are concerned, it was more difficult to localize their central anti-anxiety like action. More clear and unequirocal effects could be observed after intra-accumbens, rather than after intrahippocampal injections of tropisetron and ondansetron.
结果清楚地表明，介导5-HT1A受体激动剂抗焦虑样作用的是海马体，而非伏隔核。此外，海马体突触后5-HT1A受体可能是这类药物产生抗情绪影响的原因。就5-HT3受体拮抗剂而言，定位其在中枢的抗焦虑样作用更为困难。在伏隔核内注射托烷司琼和昂丹司琼后，比在海马体内注射后能观察到更明显、更明确的效果。
