Pharmacokinetics and bioavailability of stereoisomeric analogues of ifosfamide.

Analogues of ifosfamide (IPA): racemic bromofosfamide (+/-)-(R,S)-KM 135, racemic chlorobromofosfamide (+/-)-(R,S)-CBM 4a and levorotatory enantiomer of chlorobromofosfamide (-)-(S)-CBM 11 belong to the known group of oxazaphosphorines. Antitumor activity of those three selected compounds, investigated in the Institute of Immunology and Experimental Therapy, Polish Academy of Sciences in Wrocław against L1210 leukemia, Lewis lung carcinoma and B16 melanoma tumor model system showed cytostatic activity higher than the referential - ifosfamide [1]. These interesting data prompted us to conduct the preclinical pharmacokinetic studies in rats.