Tutka P, Młynarczyk M, Zółkowska D, Kleinrok Z
Department of Pharmacology, Medical University School, Lublin, Poland.
Acta Physiol Hung. 1996;84(4):471-2.
We investigated the influence of NG-nitro-L-arginine (NNA), the inhibitor of nitric oxide synthese, on seizures induced by 4-aminopyridine (4-AP), the K+ channel antagonist, in mice NNA (5, 10 and 40 mg/kg, i.p.) significantly reduced the respectives CD50 of 4-AP from 9.0 to 7.6, 7.5 and 6.8 for clonic seizures, and from 9.2 to 7.7, 7.5 and 6.9 for tonic seizures and death. Lower doses of NNA (1.0 and 2.5 mg/kg) had no effect on 4-AP-induced convulsions and lethality. Our results indicate that 4-AP-induced seizures may be, at least in part, dependent on nitric oxide level.
我们研究了一氧化氮合成酶抑制剂NG-硝基-L-精氨酸（NNA）对钾通道拮抗剂4-氨基吡啶（4-AP）诱发的小鼠癫痫发作的影响。NNA（5、10和40毫克/千克，腹腔注射）显著降低了4-AP的相应半数惊厥剂量（CD50），阵挛性癫痫发作从9.0降至7.6、7.5和6.8，强直性癫痫发作和死亡从9.2降至7.7、7.5和6.9。较低剂量的NNA（1.0和2.5毫克/千克）对4-AP诱发的惊厥和致死率没有影响。我们的结果表明，4-AP诱发的癫痫发作可能至少部分依赖于一氧化氮水平。
