肝微粒体氨基比林脱甲基酶活性对马氟烷肝毒性的影响。
The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse.
作者信息
Gopinath G, Ford E J
出版信息
J Pathol. 1976 Jun;119(2):105-12. doi: 10.1002/path.1711190205.
PMID:932876
Abstract
The hepatotoxic effect of oral halothane in the horse is increased by pretreatment with phenobarbitone or DDT but not by chlorpromazine. Phenobarbitone and DDT increase the activity of hepatic amidopyrine N-demethylase but chlorpromazine does not. Carbon disulphide protects the liver of the horse against halothane.
摘要
苯巴比妥或滴滴涕预处理会增强氟烷对马的肝毒性作用，但氯丙嗪不会。苯巴比妥和滴滴涕会增加肝脏氨基比林N-脱甲基酶的活性，但氯丙嗪不会。二硫化碳可保护马的肝脏免受氟烷的损害。
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