Whyatt P L, Slywka G W, Melikian A P, Meyer M C
J Pharm Sci. 1976 May;65(5):652-6. doi: 10.1002/jps.2600650505.
The bioavailability of single lots of 250-mg ampicillin capsules, available from 17 distributors and/or manufactures, was determined. Each product was evaluated in terms of the serum ampicillin levels achieved at 1, 2, 3, 4, 6, and 8 hr postadministration, the peak serum levels, the time of peak serum level, and the area under the serum level-time curve. There was no statistically significant difference (p is greater than 0.05) between any of the 17 products tested.
对来自17个经销商和/或生产商的单批250毫克氨苄青霉素胶囊的生物利用度进行了测定。每种产品根据给药后1、2、3、4、6和8小时达到的血清氨苄青霉素水平、血清峰值水平、血清峰值水平出现的时间以及血清水平-时间曲线下的面积进行评估。所测试的17种产品之间均无统计学显著差异（p大于0.05）。
