Swinyard E A, Woodhead J H, Petersen R V
J Pharm Sci. 1976 May;65(5):733-4. doi: 10.1002/jps.2600650525.
The data presented suggest that the intravenous or intraperitoneal administration of bis(2-ethylhexyl) phthalate prolongs hexobarbital sleep time in mice and rats by enlarging the lipophilic pool, a phenomenon that can be replicated by pretreatment of the animals with olive oil. These results call attention to the importance of considering the physical characteristics of a substance when evaluating its effect on a pharmacologically active agent.
所呈现的数据表明，静脉注射或腹腔注射邻苯二甲酸二（2-乙基己基）酯可通过扩大亲脂性池来延长小鼠和大鼠的己巴比妥睡眠时间，这一现象可用橄榄油对动物进行预处理来复制。这些结果提醒人们，在评估一种物质对药理活性剂的作用时，要注意考虑该物质的物理特性。
