Lerk C F, Schoonen A J, Fell J T
J Pharm Sci. 1976 Jun;65(6):843-7. doi: 10.1002/jps.2600650611.
Contact angles of pharmaceutical powders were determined by the h-epsilon method, which consists essentially of measuring the maximum height of a drop of liquid fomed on a presaturated compact of the material. Determinations with aspirin as the test material indicate that the measured value is independent of the particle size of the powder and the porosity of the cake. The method was extended to include determinations on mixed powder systems. The results show that the hydrophobic material dominates with large particle-size powders; with small particle sizes, a linear relationship between the cosine of the contact angle of the mixed system and the proportion of the components is obtained. Results are presented for a wide variety of materials of pharmaceutical interest.
药用粉末的接触角通过h-ε法测定，该方法主要包括测量在预先饱和的材料压块上形成的液滴的最大高度。以阿司匹林为测试材料的测定表明，测量值与粉末的粒径和滤饼的孔隙率无关。该方法被扩展到包括对混合粉末体系的测定。结果表明，对于大粒径粉末，疏水材料起主导作用；对于小粒径粉末，混合体系接触角的余弦值与各组分比例之间呈线性关系。文中给出了多种具有药用价值材料的测定结果。
