各种药物在体外对蒙脱石的吸附作用。

In vitro adsorption of various pharmaceutical to montmorillonite.

作者信息

McGinity J W, Lach J L

出版信息

J Pharm Sci. 1976 Jun;65(6):896-902. doi: 10.1002/jps.2600650623.

Abstract

Dissolution and dialysis studies showed that cationic drugs and certain nonionic drugs bind strongly to montmorillonite clay. The quantity of drug bound by one unit of clay varied considerably. Anionic drugs were weakly bound, and less bioavailabilty problems would be anticipated with these medicinals. The mechanism of binding of cationic drugs to montmorillonite was proposed as a two-step process: a cation-exchange reaction followed by strong surface chemisorption.

摘要

溶出度和透析研究表明，阳离子药物和某些非离子药物与蒙脱石粘土有很强的结合力。一单位粘土结合的药物量差异很大。阴离子药物结合较弱，预计这些药物的生物利用度问题较少。阳离子药物与蒙脱石结合的机制被认为是一个两步过程：阳离子交换反应，随后是强烈的表面化学吸附。