Simultaneous quantitative GLC determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in a cold tablet preparation.

A GLC method was developed for the simultaneous determinations of chlorpheniramine maleate and phenylpropanolamine hydrocholride in a cold tablet preparation containing a large amount of aspirin. The method utilizes a solid sampling device to eliminate interference from solvent, and it is rapid and precise. The total analysis time is less than 1.5 hr, thereby permitting its use for quality control purposes.