艾滋病病毒蛋白酶与艾滋病治疗方法。

The HIV protease and therapies for AIDS.

作者信息

Korant B D, Rizzo C J

机构信息

Molecular Biology Department, DuPont Merck Pharmaceutical Co., Wilmington, DE 19880-0336, USA.

出版信息

Adv Exp Med Biol. 1997;421:279-84. doi: 10.1007/978-1-4757-9613-1_37.

DOI:10.1007/978-1-4757-9613-1_37

PMID:9330709

Abstract

New, potent therapies for HIV disease are available, based on synthetic inhibitors of the viral protease, an essential viral enzyme. The results in clinical trials have been impressive with most treated individuals benefiting in terms of reduced quantity of detectable virus, enhanced numbers of CD4 lymphocytes and improvements in quality and duration of life. However, there are some remaining negatives associated with the new drugs, including high cost, side effects and appearance of drug-resistant strains of HIV. Problems and future prospects for use of protease inhibitors and alternate approaches in AIDS are discussed.

摘要

基于对病毒蛋白酶（一种重要的病毒酶）的合成抑制剂，现已出现针对艾滋病毒疾病的新型有效疗法。临床试验结果令人瞩目，大多数接受治疗的个体在可检测病毒数量减少、CD4淋巴细胞数量增加以及生活质量和寿命改善方面都有所获益。然而，这些新药仍存在一些负面问题，包括成本高昂、副作用以及艾滋病毒耐药菌株的出现。本文讨论了蛋白酶抑制剂的使用问题及未来前景，以及艾滋病治疗的其他方法。