癌胚抗原黏附分子：具有信号调节特性的多功能蛋白。
CEA adhesion molecules: multifunctional proteins with signal-regulatory properties.
作者信息
Obrink B
机构信息
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden.
出版信息
Curr Opin Cell Biol. 1997 Oct;9(5):616-26. doi: 10.1016/s0955-0674(97)80114-7.
Abstract
The carcinoembryonic antigen family comprises a large number of complex molecules, several of which possess cell adhesion activities. The primordial adhesion molecules of this family are the cell-cell adhesion molecules (C-CAMs), which have been found to be multifunctional, signal-regulatory proteins. C-CAMs inhibit tumor growth, interact with calmodulin, protein tyrosine kinases and protein tyrosine phosphatases, and are subject to specific dimerization reactions. These new insights indicate that C-CAMs are important regulators of cellular functions.
摘要
癌胚抗原家族由大量复杂分子组成，其中一些具有细胞黏附活性。该家族的原始黏附分子是细胞间黏附分子（C-CAMs），已发现它们是多功能的信号调节蛋白。C-CAMs可抑制肿瘤生长，与钙调蛋白、蛋白酪氨酸激酶和蛋白酪氨酸磷酸酶相互作用，并会发生特定的二聚化反应。这些新见解表明C-CAMs是细胞功能的重要调节因子。
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本文引用的文献
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