Mann D M
Department of Pathological Sciences, University of Manchester, United Kingdom.
Neurobiol Aging. 1997 Jul-Aug;18(4 Suppl):S51-2. doi: 10.1016/s0197-4580(97)00069-9.
Apart from providing a potential framework for a universally acceptable protocol for the pathological diagnosis of Alzheimer's disease, the Working Party has dispelled one of the major myths of so-called normal aging, namely that minor degrees of Alzheimer-type change (i.e., plaques and tangles) are not the product of growing older alone but should always be regarded as pathological, as they probably represent the tissue substrate of incipient Alzheimer's disease. Establishment of the pathological criteria for such preclinical disease will be of equal importance as that associated with clinical change.
除了为阿尔茨海默病的病理诊断提供一个普遍可接受的方案的潜在框架外，该工作小组还消除了所谓正常衰老的一个主要误解，即轻度阿尔茨海默型改变（即斑块和缠结）并非仅由衰老产生，而应始终被视为病理性的，因为它们可能代表早期阿尔茨海默病的组织基础。建立这种临床前疾病的病理标准将与临床变化相关的标准具有同等重要性。
