Savage J R
J Med Genet. 1976 Apr;13(2):103-22. doi: 10.1136/jmg.13.2.103.
A detailed survey is given of the types and classification of primary structural changes that can be induced in chromosomes and observed at the first metaphase after the initial damage. Comments upon identification and scoring are given for the benefit of new workers. The annotation concludes with a brief discussion of the potential relationships between the primary types, and the secondary or derived types encountered in clinical studies.
本文详细综述了可在染色体中诱导产生并在初始损伤后的第一次中期观察到的初级结构变化的类型和分类。为帮助新研究人员,对识别和计分进行了说明。注释最后简要讨论了初级类型与临床研究中遇到的次级或衍生类型之间的潜在关系。