Department of Surgery, Faculty of Medicine, Cairo University, Egypt.
Int Surg. 1997 Apr-Jun;82(2):175-81.
Chronic inflammatory and vascular disorders of the foot frequently present 2 problems: slow improvement, resulting in long-term therapy, and episodes of critical complications that may seriously threaten the foot. Particularly in a foot with compromised perfusion, the systemic administration of therapeutic agents may be insufficient. Retrograde venous perfusion, RVP, is a new approach that was recently employed for treatment of diabetic neuropathic pedal ulcers.
In this paper, RVP was utilized in 24 patients with diabetic or non-diabetic foot disorders (infection, ulcers and critical pedal ischemia). Employed agents were infused according to predetermined regimens and included: antibiotics, deproteinized hemodialysate and PGE1.
The target lesions were eliminated in 20 patients and improved in the others.
The presented therapy proved to be a useful adjunct to conservative or surgical treatment in the studied disorders. Its main impact was in shortening the duration of therapy and overcoming critical complications threatening the foot.
足部的慢性炎症和血管疾病常常呈现两个问题：改善缓慢，导致长期治疗，以及可能严重威胁足部的严重并发症发作。特别是在灌注受损的足部，全身给药治疗可能不足。逆行静脉灌注（RVP）是一种最近用于治疗糖尿病性神经性足部溃疡的新方法。
本文中，24例患有糖尿病或非糖尿病足部疾病（感染、溃疡和严重足部缺血）的患者接受了逆行静脉灌注治疗。根据预定方案注入所用药物，包括：抗生素、去蛋白血液透析液和前列腺素E1。
20例患者的目标病变得以消除，其他患者病情有所改善。
在研究的疾病中，所提出的治疗方法被证明是保守治疗或手术治疗的有用辅助手段。其主要作用是缩短治疗时间并克服威胁足部的严重并发症。
