Berman I R, Iliescu H, Ranson J H, Eng K
J Trauma. 1976 Jun;16(6):471-80.
Massive transfusion of bank blood has been implicated as a major etiologic factor in the evolution of pulmonary insufficiency after injury. In spite of the demonstration of significant debris, including aggregates, in stored blood, a precise and reproducible pulmonary effect of transfusion has not previously been demonstrated. Since clinical pulmonary insufficiency is frequently accompanied by increased lung water, these experiments were designed to measure pulmonary capillary permeability and its response to transfusion of blood and blood components in rats. These experiments demonstrate that: 1) the rat lung is a target organ with regard to blood transfusion; 2) the lung lesion with transfusion is attributable, at least in part, to a selective and acute increase in pulmonary capillary permeability; 3) pulmonary capillary permeability is highly responsive to viable platelets; 4) prolonged storage of blood in polyvinyl chloride containers may enhance its ability to induce pulmonary capillary permeability; 5) increased capillary permeability with transfusion is largely eliminated when platelets and buffy coat are eliminated.
大量输注库存血被认为是损伤后发生肺功能不全演变过程中的一个主要病因。尽管已证实在库存血中存在包括聚集体在内的大量碎屑，但此前尚未证实输血对肺部有精确且可重复的影响。由于临床肺功能不全常伴有肺水增加，因此设计了这些实验来测量大鼠肺毛细血管通透性及其对输血和血液成分的反应。这些实验表明：1）就输血而言，大鼠肺是一个靶器官；2）输血所致的肺部病变至少部分归因于肺毛细血管通透性的选择性急性增加；3）肺毛细血管通透性对有活力的血小板高度敏感；4）血液在聚氯乙烯容器中长时间储存可能会增强其诱导肺毛细血管通透性的能力；5）去除血小板和白膜后，输血引起的毛细血管通透性增加在很大程度上可消除。
