Plasma protein binding of theophylline in late pregnancy in rat.
作者信息
Smeaton T C, Sultana S
机构信息
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide.
出版信息
Indian J Exp Biol. 1997 Mar;35(3):272-5.
PMID:9332173
Abstract
A single bolus dose of theophylline (Th; 5 mg/kg) was administered through the abdominal catheter in nonpregnant and pregnant rats to measure unbound fraction (fu) of Th in pregnancy. After 90 min blood samples were collected. Plasma was extracted with a solvent system comprising chloroform and isopropyl alcohol (IPA) followed by iso-cratic HPLC analysis. Results showed an increase in unbound fraction of Th in late pregnancy.
摘要
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