Wong K F, Kwong Y L, Hui P K
Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Cancer Genet Cytogenet. 1997 Oct 15;98(2):102-5. doi: 10.1016/s0165-4608(96)00415-3.
Hairy cell leukemia variant is an uncommon chronic B-cell lymphoproliferative disorder characterized clinically by splenomegaly and marked leukocytosis. Cytologically, the leukemic cells are distinguishable from those of classical hairy cell leukemia by the presence of single, central, and vesicular nucleoli. Cytogenetic information for this uncommon leukemia is scanty, although structural abnormalities involving 7q34 have been reported in few cases. We report a patient with hairy cell leukemia variant who has t(2;8)(p12;q34) but without [corrected] c-MYC oncogene rearrangement.
毛细胞白血病变异型是一种罕见的慢性B细胞淋巴增殖性疾病，临床特征为脾肿大和显著的白细胞增多。在细胞学上，白血病细胞通过存在单个、中央和泡状核仁与经典毛细胞白血病细胞相区分。尽管少数病例报告了涉及7q34的结构异常，但关于这种罕见白血病的细胞遗传学信息很少。我们报告了一名患有毛细胞白血病变异型的患者，其有t(2;8)(p12;q34)，但无[校正后]c-MYC癌基因重排。
