伴有6号染色体长臂2区3带至2区5带缺失（del(6)(q23q25)）的微囊性附属器癌的细胞遗传学和荧光原位杂交分析

Cytogenetic and fluorescence in situ hybridization analyses of a microcystic adnexal carcinoma with del(6)(q23q25).

作者信息

Wohlfahrt C, Ternesten A, Sahlin P, Islam Q, Stenman G

机构信息

Department of Pathology, Göteborg University, Gothenburg, Sweden.

出版信息

Cancer Genet Cytogenet. 1997 Oct 15;98(2):106-10. doi: 10.1016/s0165-4608(96)00417-7.

DOI:10.1016/s0165-4608(96)00417-7

PMID:9332473

Abstract

Cytogenetic analysis of a case of microcystic adnexal carcinoma (MAC) revealed three unrelated clones with the karyotypes: 46,XX,del(6)(q23q25)[17]/46,XX,1 approximately 2dmin[4]/46,XX,t(1;3) (p10;q10)[2]. Analysis of the 6q- by fluorescence in situ hybridization (FISH) showed that it had resulted from a long arm deletion. The finding of a clonal 6q deletion as the sole karyotypic change in a MAC is of special interest because we previously have identified 6q deletions in different types of malignant salivary gland tumors. This observation, together with the histopathologic similarities between salivary gland tumors and sweat gland tumors, further emphasize the histogenetic relationships between these tumor types.

摘要

对一例微囊性附属器癌（MAC）进行细胞遗传学分析，发现三个不相关的克隆，其核型分别为：46,XX,del(6)(q23q25)[17]/46,XX,1约2dmin[4]/46,XX,t(1;3)(p10;q10)[2]。通过荧光原位杂交（FISH）分析6q-，结果显示其源于长臂缺失。在MAC中发现克隆性6q缺失作为唯一的核型改变，这一发现具有特殊意义，因为我们之前在不同类型的恶性涎腺肿瘤中已鉴定出6q缺失。这一观察结果，连同涎腺肿瘤和汗腺肿瘤之间的组织病理学相似性，进一步强调了这些肿瘤类型之间的组织发生学关系。