Kwong Y L, Wong K F
University Department of Medicine, Queen Mary Hospital, Hong Kong.
Cancer Genet Cytogenet. 1997 Oct 15;98(2):137-8. doi: 10.1016/s0165-4608(96)00418-9.
Translocation (12;21)(p13;q22) is a recently characterized aberration in acute lymphoblastic leukemia, and results in the fusion of the TEL and the AML1 genes. It is the most common translocation in pediatric acute lymphoblastic leukemia (ALL), occurring in about one third of the cases. To determine the frequency of TEL/AML1 in adult ALL, we studied 4 cases of T lineage ALL and 26 cases of B lineage ALL. Only one positive case was identified, giving a very low frequency of 3.3%. In this patient, TEL/AML1 was still detectable in complete hematologic remission. The apparent age predilection of t(12;21) warrants further investigations.
易位(12;21)(p13;q22)是急性淋巴细胞白血病中最近发现的一种畸变，它导致TEL基因与AML1基因融合。这是儿童急性淋巴细胞白血病（ALL）中最常见的易位，约三分之一的病例中会出现。为了确定成人ALL中TEL/AML1的频率，我们研究了4例T系ALL和26例B系ALL。仅发现1例阳性病例，频率极低，为3.3%。在该患者中，完全血液学缓解时仍可检测到TEL/AML1。t(12;21)明显的年龄倾向性值得进一步研究。
