Mantel G D, Makin J D
Department of Obstetrics and Gynaecology, University of Pretoria, Kalafong Hospital, South Africa.
Br J Obstet Gynaecol. 1997 Oct;104(10):1180-3. doi: 10.1111/j.1471-0528.1997.tb10943.x.
To assess the effect of low dose dopamine on the urine output in postpartum pre-eclamptic or eclamptic women with oliguria.
A double blind, randomised controlled study.
The high care area of the labour ward in a teaching hospital.
Forty postpartum pre-eclamptic women with oliguria, defined as < 30 mL/hour, who have not responded to a 300 mL crystalloid fluid challenge.
Dopamine was infused at a rate of 1 to 5 microg/kg per minute, or sterile water was given as placebo in the same dilution.
Urine output, blood pressure and pulse was measured for six hours before and for six hours after the intervention.
Women who received dopamine (344 mL over 6 hours) showed a clinically and statistically significant (P = 0.0014, Mann-Whitney U test) higher median urine output compared with those receiving placebo (135 mL over 6 hours) for the duration of therapy. The respective 95% confidence intervals were 212.3 to 712.7 mL compared with 73.8 to 244.7 mL. No differences in blood pressure or pulse were found between the two groups.
The use of low dose dopamine in a labour setting improved urine output in postpartum pre-eclamptic women with oliguria who had not responded to a single fluid challenge without a detrimental effect on the blood pressure or pulse.
评估小剂量多巴胺对产后子痫前期或子痫且少尿妇女尿量的影响。
双盲、随机对照研究。
一家教学医院产房的重症监护区。
40名产后子痫前期少尿妇女，少尿定义为每小时尿量<30毫升，且对300毫升晶体液冲击试验无反应。
以每分钟1至5微克/千克的速率输注多巴胺，或以相同稀释度给予无菌水作为安慰剂。
在干预前6小时和干预后6小时测量尿量、血压和脉搏。
在治疗期间，接受多巴胺治疗的妇女（6小时内尿量为344毫升）与接受安慰剂的妇女（6小时内尿量为135毫升）相比，尿量中位数在临床和统计学上均显著更高（曼-惠特尼U检验，P = 0.0014）。各自的95%置信区间分别为212.3至712.7毫升和73.8至244.7毫升。两组之间血压或脉搏无差异。
在产房环境中，使用小剂量多巴胺可改善产后子痫前期少尿且对单次液体冲击试验无反应的妇女的尿量，且对血压或脉搏无不利影响。
