Miyamura S, Ochiai H, Terao M
Jpn J Antibiot. 1976 May;29(5):580-4.
Bonnamycin which is a new tetracycline group antibiotic isolated from a variant strain of Streptomyces rimosus and is identified chemically as doxycycline was investigated, comparing with tetracycline. The results are as follows: (1) In in vitro studies of anti-bacterial spectrum, doxycycline is widely effective against standard strains kept in our department. (2) The distribution of susceptibility of 75 Staphylococci, 62 Salmonella and 64 Shigella strains isolated from clinical materials was similar to that of tetracycline. (3) As to the therapeutic experiment in acute infection of Klebsiella pneumoniae in mice, the drugs were equally effective and the ED50 was both 70.8 mcg. (4) Doxycycline administrated orally or subcutaneously in rats was distributed in kidneys, livers, lungs and spleens at relatively high concentration among organs.
对从龟裂链霉菌变异株中分离出的一种新型四环素类抗生素博纳霉素进行了研究，其化学成分为多西环素，并与四环素进行了比较。结果如下：(1) 在体外抗菌谱研究中，多西环素对保存在我们科室的标准菌株具有广泛的有效性。(2) 从临床材料中分离出的75株葡萄球菌、62株沙门氏菌和64株志贺氏菌的药敏分布与四环素相似。(3) 关于小鼠肺炎克雷伯菌急性感染的治疗实验，两种药物同样有效，半数有效量均为70.8微克。(4) 多西环素经口服或皮下给药后，在大鼠各器官中，肾脏、肝脏、肺和脾脏中的分布浓度相对较高。
