Afflelou S, Auriacombe M, Cazenave M, Chartres J P, Tignol J
Laboratoire de Psychiatrie de l'Université Victor Segalen de Bordeaux II, Hôpital Charles-Perrens, Centre Carreire.
Encephale. 1997 May-Jun;23(3):209-17.
Rapid cycling among bipolar disorders was characterized in 1974 by Dunner and Fieve by at least 4 episodes per year, lithium resistance, female predominance. The idea of using thyroid hormones is based on frequent coexisting thyroid dysfunction. Thyroid hormones where first used in the forties, and more recently (table I) in open label and blind trials (Stancer et Persad, 1982; Bauer et Whybrow, 1990).
Open label study of levothyroxine in rapid cycling bipolar disorder.
Six subjects (4 females and 2 males, mean age 45.5 years at onset of bipolar disorder) meeting DMS III-R criteria for rapid cycling bipolar disorder were consecutively included in an open label study of levothyroxine. Subject characteristics are presented in table II.
After almost two years follow-up results appear positive in 67% of cases (2 complete remissions, 2 partial remissions and 2 failures).
Our cases, with data reported in the literature, support the potential efficacy of levothyroxine for treatment of rapid cycling bipolar disorder patients. We suggest a protocol for the good application of this potential new treatment (table III).
双相情感障碍中的快速循环型在1974年由邓纳和菲夫定义为每年至少有4次发作、对锂盐耐药且女性居多。使用甲状腺激素的想法基于频繁并存的甲状腺功能障碍。甲状腺激素在四十年代首次被使用，最近（见表一）在开放标签和盲法试验中使用（斯坦瑟和珀萨德，1982年；鲍尔和怀布罗，1990年）。
对左甲状腺素治疗快速循环型双相情感障碍进行开放标签研究。
6名符合《精神疾病诊断与统计手册》第三版修订版（DMS III-R）快速循环型双相情感障碍标准的受试者（4名女性和2名男性，双相情感障碍发病时平均年龄45.5岁）被连续纳入左甲状腺素的开放标签研究。受试者特征见表二。
经过近两年的随访，67%的病例结果呈阳性（2例完全缓解，2例部分缓解，2例无效）。
我们的病例以及文献报道的数据支持左甲状腺素治疗快速循环型双相情感障碍患者的潜在疗效。我们提出了一个关于良好应用这种潜在新疗法的方案（见表三）。
