Hola K, Brahm J, Alvo M, Cotera A, Passalacqua W, Smok G
Departamento de Medicina Interna, Hospital Clínico Universidad de Chile.
Rev Med Chil. 1996 Dec;124(12):1489-91.
We report a 30 years old male, recipient of a kidney allograft and treated with azathioprine, who eighteen days after transplantation had a clinically asymptomatic elevation of total bilirubin and alkaline phosphatases. Nineteen months later, he presented with mild ascites, with a total bilirubin of 3.5 mg/dl, alkaline phosphatases of 308 U/L (normal < 170 U/L) and a prothrombin time at 55% of control. A liver biopsy showed sinusoidal and perivenular fibrosis without inflammation, compatible with chronic venous obstruction. Hepatic veno-occlusive disease is an infrequent complication of azathioprine use.
我们报告一例30岁男性，为肾移植受者，接受硫唑嘌呤治疗，移植后18天出现总胆红素和碱性磷酸酶的临床无症状升高。19个月后，他出现轻度腹水，总胆红素为3.5mg/dl，碱性磷酸酶为308U/L（正常<170U/L），凝血酶原时间为对照值的55%。肝脏活检显示窦性和小叶静脉周围纤维化，无炎症，符合慢性静脉阻塞。肝静脉闭塞病是使用硫唑嘌呤的一种罕见并发症。
