Luo C, Liang J
Institute of Pharmacology and Toxicology, Beijing, People's Republic of China. Dr. Chunyuan
Toxicol Lett. 1997 Aug 22;92(3):195-200. doi: 10.1016/s0378-4274(97)00057-x.
A computer program (Q-test) was used to evaluate the combined toxic effects of nerve agent GF and its combined form with sarin (GB/GF) in mice. Efficacy of Jielin Injection, the 2-PAM-containing antidote used successfully in China for the treatment of organophosphate pesticide poisoning, was also evaluated and compared with HI-6 against single and combined poisonings. The two agents were basically additive in toxicity when combined. However, toxic signs (convulsions) appeared later in combined poisoning than after exposure to each agent alone. The protective ratio of Jielin Injection against GF poisoning was low but significantly higher when against poisoning by GB or combined agent. When HI-6 was substituted for 2-PAM, the antidote was more effective against poisoning by both single and combined agents. Results of in vitro reactivation of GF-inhibited human erythrocyte acetylcholinesterase by these oximes agreed with the in vivo antidotal efficacy.
使用计算机程序（Q检验）评估神经毒剂GF及其与沙林（GB/GF）的组合形式对小鼠的联合毒性作用。还评估了在中国成功用于治疗有机磷农药中毒的含解磷定的解毒剂解磷注射液的疗效，并将其与HI-6针对单一和联合中毒的疗效进行比较。两种药剂联合时毒性基本呈相加性。然而，联合中毒时的中毒症状（惊厥）比单独接触每种药剂后出现得晚。解磷注射液对GF中毒的保护率较低，但对GB或联合药剂中毒的保护率显著更高。当用HI-6替代解磷定后，该解毒剂对单一和联合药剂中毒均更有效。这些肟类化合物对GF抑制的人红细胞乙酰胆碱酯酶的体外重活化结果与体内解毒疗效一致。
