Vacca G, Battaglia A, Grossini E, Mary D A, Molinari C, Surico N
Dipartimento di Scienze Mediche, Facoltà di Medicina e Chirurgia di Novara, Università di Torino, Novara, Italy.
J Auton Nerv Syst. 1997 Sep 10;66(1-2):7-14. doi: 10.1016/s0165-1838(97)00039-8.
The present study was undertaken in anaesthetised pigs to determine the primary reflex effects of distension of the uterus on the peripheral circulation. Experiments were performed in seven pigs anaesthetised with alpha-chloralose and artificially ventilated. Blood flow in the superior mesenteric, left renal and left external iliac arteries was assessed using electromagnetic flowmeters. Distension of the uterus was performed whilst preventing changes in heart rate and aortic blood pressure by injecting 20 ml of warm Ringer solution in a balloon positioned within the viscus (mean transmural pressure of about 18 mmHg). In each pig, distension of the uterus caused decreases in all measured blood flows. In four pigs, these decreases were graded by step increments of distension. In the seven pigs, the responses of decrease in mesenteric, renal and iliac blood flows were not affected by blockade of beta-adrenergic receptors with propranolol, but were abolished by the subsequent blockade of alpha-adrenergic receptors with phentolamine. The present study showed that distension of the uterus in anaesthetised pigs primarily caused reflex vasoconstriction in the mesenteric, renal and iliac vascular beds. This reflex response was mediated by sympathetic mechanisms which involved alpha vascular adrenergic receptors.
本研究在麻醉猪身上进行，以确定子宫扩张对外周循环的主要反射效应。实验在七只用α-氯醛糖麻醉并人工通气的猪身上进行。使用电磁流量计评估肠系膜上动脉、左肾动脉和左髂外动脉的血流。通过向置于子宫内的气囊中注入20毫升温林格溶液（平均跨壁压力约为18 mmHg）来扩张子宫，同时防止心率和主动脉血压发生变化。在每只猪中，子宫扩张导致所有测量的血流减少。在四只猪中，这些减少通过逐步增加扩张程度来分级。在这七只猪中，肠系膜、肾和髂血流减少的反应不受普萘洛尔阻断β-肾上腺素能受体的影响，但随后被酚妥拉明阻断α-肾上腺素能受体所消除。本研究表明，麻醉猪的子宫扩张主要导致肠系膜、肾和髂血管床的反射性血管收缩。这种反射反应是由涉及α血管肾上腺素能受体的交感神经机制介导的。
