Kauffman C L, Sina B
Department of Dermatology, University of Maryland School of Medicine, Baltimore 21201 U.S.A.
Am J Dermatopathol. 1997 Oct;19(5):528-32. doi: 10.1097/00000372-199710000-00107.
We report a case of a patient with adenocarcinoma of the rectum with inflammatory metastases to the skin who was treated with radiation therapy and subsequently developed lymphatic obstruction with resultant extensive lymphedema of the lower extremities. Histopathologic examination and immunohistochemistry showed intralymphatic, intravascular, and interstitial malignant cells in the dermis. To our knowledge, this is the second reported case of inflammatory carcinoma arising from metastatic carcinoma of the rectum. However, tumor cell spread to the skin by three routes has not previously been demonstrated.
我们报告了一例直肠腺癌患者，其皮肤出现炎性转移，接受了放射治疗，随后出现淋巴阻塞，导致双下肢广泛淋巴水肿。组织病理学检查和免疫组化显示真皮内存在淋巴管内、血管内和间质内恶性细胞。据我们所知，这是第二例报道的由直肠转移癌引起的炎性癌病例。然而，肿瘤细胞通过三种途径扩散至皮肤此前尚未得到证实。
