Liem K F, Tremml G, Jessell T M
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA.
Cell. 1997 Oct 3;91(1):127-38. doi: 10.1016/s0092-8674(01)80015-5.
Distinct neuronal cell types are generated at characteristic times and positions in the dorsal horn of the spinal cord. We provide evidence that the identity and pattern of generation of dorsal neurons depend initially on BMP-mediated signals that derive from the epidermal ectoderm and induce dorsal midline cells of the roof plate. Roof plate cells provide a secondary source of TGFbeta-related signals that are required for the generation of distinct classes of dorsal interneurons. These inductive interactions involve both qualitative and quantitative differences in signaling by TGFbeta-related factors and temporal changes in the response of neural progenitor cells.
不同类型的神经元细胞在脊髓背角的特定时间和位置生成。我们提供的证据表明，背侧神经元的身份和生成模式最初取决于源自表皮外胚层并诱导顶板背侧中线细胞的BMP介导信号。顶板细胞提供了TGFβ相关信号的次要来源，这些信号是生成不同类别的背侧中间神经元所必需的。这些诱导相互作用涉及TGFβ相关因子信号传导的质和量的差异以及神经祖细胞反应的时间变化。
