Prossnitz E R, Ye R D
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.
Pharmacol Ther. 1997;74(1):73-102. doi: 10.1016/s0163-7258(96)00203-3.
N-formyl peptides, such as fMet-Leu-Phe, are one of the most potent chemoattractants for phagocytic leukocytes. The interaction of N-formyl peptides with their specific cell surface receptors has been studied extensively and used as a model system for the characterization of G-protein-coupled signal transduction in phagocytes. The cloning of the N-formyl peptide receptor cDNA from several species and the identification of homologous genes have allowed detailed studies of structural and functional aspects of the receptor. Recent findings that the receptor is expressed in nonhematopoietic cells and that nonformylated peptides can activate the receptor suggest potentially novel functions and the existence of additional ligands for this receptor.
N-甲酰基肽，如甲酰甲硫氨酸-亮氨酸-苯丙氨酸，是吞噬性白细胞最有效的趋化因子之一。N-甲酰基肽与其特异性细胞表面受体的相互作用已得到广泛研究，并被用作表征吞噬细胞中G蛋白偶联信号转导的模型系统。从多个物种克隆N-甲酰基肽受体cDNA并鉴定同源基因，使得对该受体的结构和功能方面进行详细研究成为可能。最近的研究发现该受体在非造血细胞中表达，并且非甲酰化肽可以激活该受体，这提示了该受体潜在的新功能以及其他配体的存在。
