Griffiths J R, Taylor N J, Howe F A, Saunders M I, Robinson S P, Hoskin P J, Powell M E, Thoumine M, Caine L A, Baddeley H
CRC Biomedical Magnetic Resonance Research Group, Division of Biochemistry, St. George's Hospital Medical School, London, UK.
Int J Radiat Oncol Biol Phys. 1997 Oct 1;39(3):697-701. doi: 10.1016/s0360-3016(97)00326-x.
Gradient-Recalled Echo (GRE) Magnetic Resonance Imaging (MRI), which detects changes in blood vessel deoxyhaemoglobin content, has been investigated as a noninvasive monitor of changes in human tumor oxygenation and blood flow, in response to carbogen (95% O2, 5% CO2) breathing.
GRE images (TE = 60 ms, TR = 200 ms, alpha = 40 degrees, 256[2] matrix) were acquired from 31 patients with primary and metastatic disease, prior to and during carbogen breathing. Three patients underwent a follow-up examination after radiotherapy.
Seventeen out of 34 tumors showed enhanced image intensity, consistent with an improvement in tumor oxygenation and blood flow, while 11 showed no response; 6 studies were technical failures. In one patient a metastatic node that had eluded orthodox investigation was visualized. A reduction in response was observed in the three patients studied postradiotherapy.
This method, which can be performed on a standard clinical MRI instrument, provides a noninvasive measurement of tumor response to oxygenation/blood flow modification. In principle, this should enable the clinician to optimize treatment protocols, such as carbogen breathing, for individual radiotherapy patients.
梯度回波（GRE）磁共振成像（MRI）可检测血管中脱氧血红蛋白含量的变化，已被用于研究作为一种无创监测手段，以观察人体肿瘤氧合和血流变化，以及对吸入卡波金（95%氧气，5%二氧化碳）的反应。
从31例患有原发性和转移性疾病的患者身上，在吸入卡波金之前和期间采集GRE图像（回波时间 = 60毫秒，重复时间 = 200毫秒，翻转角 = 40度，256[2]矩阵）。3例患者在放疗后接受了随访检查。
34个肿瘤中有17个显示图像强度增强，这与肿瘤氧合和血流改善一致，而11个无反应；6项研究为技术失败。在1例患者中，一个常规检查未发现转移淋巴结被可视化。在放疗后研究的3例患者中观察到反应降低。
这种方法可在标准临床MRI仪器上进行，提供了一种无创测量肿瘤对氧合/血流改变反应的方法。原则上，这应能使临床医生为个体放疗患者优化治疗方案，如吸入卡波金。
