高场小动物磁共振肿瘤学研究。
High-field small animal magnetic resonance oncology studies.
机构信息
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 415 East 68 Street, New York, NY 10065, USA.
出版信息
Phys Med Biol. 2014 Jan 20;59(2):R65-R127. doi: 10.1088/0031-9155/59/2/R65. Epub 2013 Dec 30.
Abstract
This review focuses on the applications of high magnetic field magnetic resonance imaging (MRI) and spectroscopy (MRS) to cancer studies in small animals. High-field MRI can provide information about tumor physiology, the microenvironment, metabolism, vascularity and cellularity. Such studies are invaluable for understanding tumor growth and proliferation, response to treatment and drug development. The MR techniques reviewed here include (1)H, (31)P, chemical exchange saturation transfer imaging and hyperpolarized (13)C MRS as well as diffusion-weighted, blood oxygen level dependent contrast imaging and dynamic contrast-enhanced MRI. These methods have been proven effective in animal studies and are highly relevant to human clinical studies.
摘要
这篇综述专注于高磁场磁共振成像（MRI）和磁共振波谱（MRS）在小动物癌症研究中的应用。高场 MRI 可以提供关于肿瘤生理学、微环境、代谢、血管生成和细胞密度的信息。这些研究对于了解肿瘤生长和增殖、对治疗的反应以及药物开发非常有价值。本文综述的磁共振技术包括（1）H、（31）P、化学交换饱和转移成像和（13）C 高极化 MRS 以及扩散加权、血氧水平依赖对比成像和动态对比增强 MRI。这些方法已在动物研究中得到证实，与人类临床研究密切相关。
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