DeSanto L W, Lillie J C, Devine K D
Laryngoscope. 1976 May;86(5):649-57. doi: 10.1288/00005537-197605000-00004.
From January, 1962, through December, 1973, 1,084 patients with cancer of the intrinsic larynx were treated at the Mayo Clinic. Of the 1,084 patients, 136 were retreated after radiation therapy failed to cure their cancer (105 glottic, 30 supraglottic, and one subglottic cancers). Recurrence of glottic cancer was generally recognized later than recurrences in the supraglottic area; likewise, glottic cancers were more advanced at recurrence than supraglottic growths. When feasible, conservation surgery was carried out on both glottic and supraglottic growths. Unfortunately, many growths were too advanced for conservation surgery by the time recurrence was recognized. The concept of "radiate-and-watch" for early glottic and supraglottic cancers is designed to save larynges. The concept is not supported by this study.
1962年1月至1973年12月期间，梅奥诊所共治疗了1084例喉内癌患者。在这1084例患者中，有136例在放射治疗未能治愈癌症后接受了再次治疗（105例声门癌、30例声门上癌和1例声门下癌）。声门癌的复发通常比声门上区域的复发被发现得更晚；同样，声门癌复发时比声门上肿瘤更晚期。在可行的情况下，对声门和声门上肿瘤都进行了保留手术。不幸的是，当复发被发现时，许多肿瘤对于保留手术来说已经过于晚期。早期声门和声门上癌的“放疗并观察”概念旨在挽救喉部。这项研究不支持这一概念。
