合成的腔内胆囊收缩素释放因子（LCRF）片段（1-35）对清醒大鼠胰腺外分泌的刺激作用。

Stimulatory effect of synthetic luminal cholecystokinin releasing factor (LCRF) fragment (1-35) on pancreatic exocrine secretion in conscious rats.

作者信息

Miyasaka K, Funakoshi A

机构信息

Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.

出版信息

Pancreas. 1997 Oct;15(3):310-3. doi: 10.1097/00006676-199710000-00015.

DOI:10.1097/00006676-199710000-00015

PMID:9336797

Abstract

The effects of a synthetic putative luminal cholecystokinin (CCK) releasing factor (LCRF) fragment (1-35) on pancreatic exocrine secretion were examined in conscious Wistar rats and a mutant strain of rats lacking the CCK-A receptor. Intraduodenal injection of graded doses of the LCRF fragment induced biphasic responses in Wistar rats. The injection of 0.1 microgram of the LCRF fragment produced a maximal response, while 1 microgram produced a lower response. No significant effect was observed in rats lacking the CCK-A receptor. The synthetic LCRF fragment stimulated pancreatic secretion via CCK-A receptors in conscious rats.

摘要

在清醒的Wistar大鼠和缺乏CCK - A受体的突变大鼠品系中，研究了一种合成的假定管腔胆囊收缩素（CCK）释放因子（LCRF）片段（1 - 35）对胰腺外分泌的影响。向十二指肠内注射不同剂量的LCRF片段可在Wistar大鼠中诱导双相反应。注射0.1微克的LCRF片段产生最大反应，而注射1微克产生较低反应。在缺乏CCK - A受体的大鼠中未观察到显著影响。合成的LCRF片段通过清醒大鼠的CCK - A受体刺激胰腺分泌。