Sovová V, Sloncová E, Fric P
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Folia Biol (Praha). 1997;43(3):101-4.
Remarkable differences in the levels of alkaline phosphatase and arginase were found in colorectal cell lines tested. In HT-29 cells, which are extremely sensitive to the induction of cell differentiation, very low levels of arginase were detected. On the other hand, high levels of arginase were present in cell lines derived from highly malignant tumours. Both findings support a prognostic significance of arginase activity in colorectal carcinomas.
在所检测的结肠直肠癌细胞系中，碱性磷酸酶和精氨酸酶水平存在显著差异。在对细胞分化诱导极其敏感的HT - 29细胞中，检测到极低水平的精氨酸酶。另一方面，源自高恶性肿瘤的细胞系中存在高水平的精氨酸酶。这两个发现均支持精氨酸酶活性在结肠癌中的预后意义。
