Dupuy R, Mercié P, Neau D, Longy-Boursier M, Conri C
Internal Medicine and Vascular Diseases Department, Saint-André Hospital, Bordeaux Teaching Hospital, France.
Rev Rhum Engl Ed. 1997 Jul-Sep;64(7-9):500-3.
Giant cell arteritis is an inflammatory disease that can affect the arteries anywhere in the body. Two cases are reported in which the arteries of the lower limbs were involved. Intermittent claudication with a walking distance of only 30 m was the inaugural manifestation in both cases. A biopsy of the superficial femoral artery provided the diagnosis in the first case. Ergotamine toxicity was considered initially in the second case. Acute ischemia and gangrene requiring amputation can complicate giant cell arteritis of the lower limbs and consequently corticosteroid therapy in an effective dose should be given as soon as the diagnosis is made. The inflammatory arterial lesions improve under therapy, but irreversible fibrosis with stenosis can develop if treatment is initiated late.
巨细胞动脉炎是一种可影响身体任何部位动脉的炎症性疾病。本文报告了两例累及下肢动脉的病例。两例患者的首发表现均为间歇性跛行，步行距离仅30米。第一例通过股浅动脉活检确诊。第二例最初考虑为麦角胺中毒。下肢巨细胞动脉炎可并发急性缺血和坏疽，需要截肢，因此一旦确诊应立即给予有效剂量的皮质类固醇治疗。治疗后炎症性动脉病变可改善，但如果治疗开始较晚，可出现不可逆的纤维化并伴有狭窄。
