静脉注射免疫球蛋白用于预防早产儿败血症

Intravenous immunoglobulin for sepsis prevention in preterm infants.

作者信息

Tanzer F, Yazar N, Hakgüdener Y, Kafali G

机构信息

Department of Pediatrics, Cumhuriyet University Faculty of Medicine, Sivas.

出版信息

Turk J Pediatr. 1997 Jul-Sep;39(3):341-5.

PMID:9339113

Abstract

The aim of this study was to investigate whether intravenous immunoglobulin (IVIG) can prevent sepsis in premature newborn infants. The study group consisted of 80 preterm newborn infants, who were divided into two groups: 40 preterm newborns received IVIG prophylactically (group A) and the control group (group B, n = 40) did not receive IVIG. IVIG was given at a dose of 500 mg/kg to infants. weighing greater than 1500 g, and 700 mg/kg to those weighing less than 1500 g at birth on days one, two and eight of life. By two, eight and 12 days of age, the treatment group had significantly greater IgG concentrations than the control group. Mortality was 7.5 percent (3/40) in group A and 27.5 percent (11/40) in group B (p < 0.01). Bacteremia was determined in three blood cultures in group A and eight in group B, particularly S.aureus and S.enteritis.

摘要

本研究的目的是调查静脉注射免疫球蛋白（IVIG）能否预防早产新生儿败血症。研究组由80名早产新生儿组成，他们被分为两组：40名早产新生儿接受IVIG预防性治疗（A组），对照组（B组，n = 40）未接受IVIG。对出生体重超过1500克的婴儿，IVIG给药剂量为500毫克/千克，对出生体重低于1500克的婴儿，在出生后的第1、2和8天，给药剂量为700毫克/千克。到2日龄、8日龄和12日龄时，治疗组的IgG浓度显著高于对照组。A组的死亡率为7.5%（3/40），B组为27.5%（11/40）（p < 0.01）。A组的三次血培养中检测到菌血症，B组为八次，尤其是金黄色葡萄球菌和肠炎链球菌。