Hainaut P
Unité des mécanismes de la cancérogenèse, Centre international de recherche sur le cancer, Lyon, France.
Bull Cancer. 1997 Jul;84(7):747-51.
The p53 protein is a transcription factor activated in response to DNA-damaging agents (such as chemical or physical carcinogens) and which plays multiple role in the control of proliferation and survival of cells exposed to genotoxic stress. Recent developments in the analysis of the crystal structure of p53 help us to understand the exact role of the various domains of the protein, as well as the impact of the mutations which are frequently found in cancers. In the future, this structural approach may significantly contribute to the interpretation of the pathological consequences of p53 mutations.
p53蛋白是一种转录因子，在受到DNA损伤剂（如化学或物理致癌物）刺激时被激活，并在控制暴露于基因毒性应激的细胞的增殖和存活中发挥多种作用。p53晶体结构分析的最新进展有助于我们了解该蛋白各个结构域的确切作用，以及癌症中常见突变的影响。未来，这种结构方法可能会对解释p53突变的病理后果做出重大贡献。
