Freitag A
Med J Aust. 1976 Apr 3;1(14):478-9.
Intravenous injections of aminophylline (250 mg) and tablets of theophylline (Neulin) (400 mg) were given, on separate occasions, to 10 patients with partially reversible severe airway obstruction. The dose of aminophylline was shown to be inadequate on the basis of the unsatisfactory plasma theophylline levels and a poor ventilatory response. Two hours after oral administration of theophylline, a mean plasma theophylline concentration in the optimal range (10 to 20 mug/ml) was reached, and a consistent improvement in the mean forced expiratory volume in one second (FEV1) occurred. A further large improvement in FEV1 after inhalation of salbutamol showed that the improvement in ventilation with the theophylline tablets, although consistent, was less than maximal.
分别对10例患有部分可逆性严重气道阻塞的患者进行了静脉注射氨茶碱（250毫克）和口服茶碱片（纽林）（400毫克）。基于不理想的血浆茶碱水平和较差的通气反应，氨茶碱的剂量显示不足。口服茶碱两小时后，血浆茶碱浓度达到最佳范围（10至20微克/毫升），一秒用力呼气量（FEV1）出现持续改善。吸入沙丁胺醇后FEV1进一步大幅改善，表明茶碱片带来的通气改善虽持续，但未达最大程度。
