人类视神经的扩散加权成像：评估多发性硬化症视神经炎的新方法。
Diffusion-weighted imaging of the human optic nerve: a new approach to evaluate optic neuritis in multiple sclerosis.
作者信息
Iwasawa T, Matoba H, Ogi A, Kurihara H, Saito K, Yoshida T, Matsubara S, Nozaki A
机构信息
Department of Radiology, Yokohama City University, School of Medicine, Japan.
出版信息
Magn Reson Med. 1997 Sep;38(3):484-91. doi: 10.1002/mrm.1910380317.
The apparent diffusion coefficient (ADC) in the optic nerve was measured from diffusion-weighted magnetic resonance imaging using an intravoxel incoherent motion (IVIM) sequence. The subjects were seven normal volunteers and eight patients with multiple sclerosis (MS) with a total of four optic nerves with acute neuritis and nine nerves with chronic neuritis. The mean ADC (4.18 +/- 1.13 x 10(-3) mm2/s, n = 9) in the optic nerves with chronic neuritis was significantly higher than that in normal volunteers (1.56 +/- 0.675 x 10(-3) mm2/s, n = 14) and that in the nerves with acute neuritis (0.94 +/- 0.43 x 10(-3) mm2/s n = 4) (P < 0.001). The ADC is useful in assessing MS foci in the optic nerves.
使用体素内不相干运动（IVIM）序列，通过扩散加权磁共振成像测量视神经中的表观扩散系数（ADC）。受试者包括7名正常志愿者和8例多发性硬化症（MS）患者，共有4条急性神经炎视神经和9条慢性神经炎视神经。慢性神经炎视神经的平均ADC（4.18±1.13×10⁻³mm²/s，n = 9）显著高于正常志愿者（1.56±0.675×10⁻³mm²/s，n = 14）和急性神经炎视神经（0.94±0.43×10⁻³mm²/s，n = 4）（P < 0.001）。ADC有助于评估视神经中的MS病灶。
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