Kayajanian G
Regul Toxicol Pharmacol. 1997 Aug;26(1 Pt 1):134-7. doi: 10.1006/rtph.1997.1129.
An ad hoc panel of dioxin experts convened by EPA's Science Advisory Board found the Agency's claim of cancer causation by dioxin unacceptable. This paper uses the very same two studies [Fingerhut (NIOSH) and Kociba] EPA relied upon to test the observations made in an unused third study [Bertazzi] to conclude that dioxin is (1) a promoter blocker of certain cancers, including all the cancers Agency scientists claimed dioxin promoted; (2) a promoter of some other cancers that EPA scientists failed to identify; and (3) a net anticarcinogen. Three independent total tumor reductions provide evidence of both cancer prevention and quantifiable risk reductions tied to specific dioxin levels. The author indirectly suggests a general cancer prevention treatment, even for cancers already initiated.
美国环境保护局科学顾问委员会召集的一个二噁英专家特别小组发现,该机构关于二噁英致癌的说法不可接受。本文使用了美国环境保护局所依赖的两项研究[芬格胡特(美国国家职业安全与健康研究所)和科西巴]来检验在一项未使用的第三项研究[贝尔塔齐]中所做的观察结果,以得出以下结论:(1)二噁英是某些癌症的促癌剂阻断剂,包括该机构科学家声称二噁英能促进的所有癌症;(2)二噁英是美国环境保护局科学家未能识别的其他一些癌症的促癌剂;(3)二噁英是一种净抗癌剂。三项独立的肿瘤总数减少提供了癌症预防以及与特定二噁英水平相关的可量化风险降低的证据。作者间接提出了一种普遍的癌症预防疗法,甚至适用于已经引发的癌症。