Ozawa H, Hironaka Y
Nihon Yakurigaku Zasshi. 1976 Apr;72(3):331-40.
Hypotensive effect of dl-Mandelamidine (Olmidine, MA) in combination with some established antihypertensive drugs was studied in conscious normotensive rats. The mean blood pressure and heart rate were measured by means of a pressure transducer via a polyethylene tube inserted into the abdominal aorta of rat according to the method described by Weeks. The results obtained were as follows; 1) The hypotensive effects of guanethidine and hydrochlorothiazide were enhanced in combination with MA. 2) The hypotensive effect of reserpine was reduced by MA. 3) The hypotensive effects of clonidine, C6, propranolol and hydralazine were uneffected by MA. On the other hand, changes in heart rate induced by reserpine and C6 were increased by MA, however, those induced by guanethidine, clonidine propranolol and hydralazine were decreased by MA. The slight decrease in heart rate induced by hydrochlorothiazide was uneffected by MA. In view of our data, it is considered important that investigation of the interaction of antihypertensive drugs be done using conscious animals, as these drugs will be clinically prescribed.
在清醒的正常血压大鼠中研究了消旋扁桃胍定（奥美定，MA）与一些已有的抗高血压药物联合使用时的降压作用。按照Weeks所描述的方法，通过插入大鼠腹主动脉的聚乙烯管，利用压力传感器测量平均血压和心率。获得的结果如下：1）胍乙啶和氢氯噻嗪与MA联合使用时降压作用增强。2）利血平的降压作用被MA减弱。3）可乐定、C6、普萘洛尔和肼屈嗪的降压作用不受MA影响。另一方面，MA使利血平和C6引起的心率变化增加，然而，MA使胍乙啶、可乐定、普萘洛尔和肼屈嗪引起的心率变化减少。氢氯噻嗪引起的轻微心率下降不受MA影响。鉴于我们的数据，考虑到这些抗高血压药物将用于临床处方，使用清醒动物进行抗高血压药物相互作用的研究很重要。
