Poza J J, Cobo A M, Martí-Massó J F
Servicio de Neurologia, Hospital Ntra, Sra. de Aránzazu, San Sebastián, Guĩpúzcoa, España.
Rev Neurol. 1997 Aug;25(144):1194-7.
To determine the frequency and characteristics of the neuropathy associated with arteriosclerosis.
A prospective clinical and electrophysiological study was made of 29 male patients with arteriosclerosis, in whom other causes of polyneuropathy had been excluded.
Eleven patients complained of paresthesiae (mostly mild). In 11 patients there were signs of polyneuropathy on clinical examination. Neurophysiological studies were abnormal in 11 patients, suggesting the presence of predominantly sensitive axonal neuropathy. In five patients with paresthesiae both physical examination and electrophysiological studies were normal. In 17 patients there were changes in the somatosensory evoked potentials. The brainstem auditory evoked potentials of 27 patients were suggestive of diffuse changes in central nervous conduction, together with super-imposed focal lesions. There were no differences as regards age, signs of disease in the legs or of the involvement of widespread illness, whether they were smokers, ex-smokers or non-smokers, the number of cigarettes smoked daily or the total duration of the smoking habit between the patients with and without clinical or electrophysiological polyneuropathy.
Approximately one third of the patients with arteriosclerosis have clinical or electrophysiological signs suggestive of predominantly sensitive axonal polyneuropathy. In some cases the patients had paresthesia but no changes were seen on physical or electrophysiological examination. The evoked potentials showed diffuse changes in central nervous conduction, and in some cases this was associated with signs of focal lesions.
确定与动脉硬化相关的神经病变的发生率及特征。
对29例排除了其他多发性神经病病因的男性动脉硬化患者进行了一项前瞻性临床和电生理研究。
11例患者主诉感觉异常（大多为轻度）。11例患者临床检查有多发性神经病体征。11例患者神经生理学研究异常，提示主要存在感觉性轴索性神经病。5例有感觉异常的患者体格检查和电生理研究均正常。17例患者体感诱发电位有改变。27例患者的脑干听觉诱发电位提示中枢神经传导有弥漫性改变，并伴有局灶性病变。有无临床或电生理性多发性神经病的患者在年龄、腿部疾病体征或全身性疾病累及情况、是否吸烟、既往吸烟与否、每日吸烟支数或吸烟习惯总时长方面均无差异。
约三分之一的动脉硬化患者有提示主要为感觉性轴索性多发性神经病的临床或电生理体征。在某些情况下，患者有感觉异常，但体格检查或电生理检查未见改变。诱发电位显示中枢神经传导有弥漫性改变，在某些情况下这与局灶性病变体征相关。
