Bertaglia E, Ramondo A, Cacciavillani L, Isabella G, Cardaioli P, Marzari A, Tona F, Maddalena F, Chioin R
UCIC, Cattedra di Cardiologia, Padova.
Cardiologia. 1997 Jul;42(7):737-41.
Primary percutaneous transluminal coronary angioplasty (PTCA) for acute myocardial infarction (AMI) allows to obtain a higher reperfusion rate in the culprit vessel than thrombolytic therapy, reducing the incidence of death, non fatal reinfarction and recurrent ischemia. The aim of this study was to test the in-hospital and mid-term results of an early invasive strategy with PTCA in patients with AMI. Thirty-four patients with AMI underwent coronary angiography within 3 hours from the onset of symptoms. Twenty-four patients had anterior AMI and 3 were in cardiogenic shock. Three patients, 1 without significant lesions and 2 with multivessel diffuse coronary disease, were left out of the procedure, and 31 patients underwent PTCA. Twenty-six lesions were total occlusions with TIMI flow 0.A TIMI flow 1 was present in the other 5 vessels. Stent deployment was decided for 16 lesions (52%). Primary success (TIMI flow 3 with mean residual stenosis of 15 +/- 20%) was obtained in 30 patients (97%). In 1 patient recanalization of the anterior descending coronary artery was not possible due to tortuosity of the abdominal and thoracic aorta. At pre-discharge angiography a good result was confirmed in 24/25 patients. After 6 months only 1 patient (3%) underwent a new PTCA for recurrent angina. In conclusion, primary PTCA for AMI within 3 hours of symptom onset allows good in-hospital and mid-term results with a low rate of complications.
急性心肌梗死(AMI)的直接经皮冠状动脉腔内血管成形术(PTCA)与溶栓治疗相比,能使罪犯血管获得更高的再灌注率,降低死亡、非致命性再梗死和反复缺血的发生率。本研究的目的是检验AMI患者早期采用PTCA的侵入性策略的院内及中期结果。34例AMI患者在症状发作后3小时内接受了冠状动脉造影。24例为前壁AMI,3例处于心源性休克状态。3例患者被排除在该手术之外,其中1例无明显病变,2例有多支弥漫性冠状动脉疾病,31例患者接受了PTCA。26处病变为TIMI血流0级的完全闭塞病变。另外5处血管TIMI血流为1级。16处病变(52%)决定进行支架置入。30例患者(97%)取得了主要成功(TIMI血流3级,平均残余狭窄为15±20%)。1例患者因腹主动脉和胸主动脉迂曲,无法实现前降支冠状动脉再通。出院前血管造影显示,25例患者中有24例结果良好。6个月后,仅1例患者(3%)因复发性心绞痛接受了再次PTCA。总之,症状发作3小时内对AMI进行直接PTCA可获得良好的院内及中期结果,并发症发生率较低。