接受无创持续气道正压通气（nCPAP）治疗的阻塞性睡眠呼吸暂停综合征患者会减重吗？

[Do patients with obstructive sleep apnea syndrome treated with nCPAP therapy lose weight?].

作者信息

Hein H, Kirsten D, Magnussen H

机构信息

Krankenhaus Grosshansdorf der LVA der Freien und Hansestadt Hamburg, Zentrum für Pneumologie und Thoraxchirurgie.

出版信息

Pneumologie. 1997 Aug;51 Suppl 3:776-8.

PMID:9340639

Abstract

A simple therapy for obstructive sleep apnoea syndrome is weight reduction, which we always recommend before initiating and maintaining nCPAP-therapy. We documented the body weight of 123 patients (9 women, 114 men; age 53.8 +/- 10 years, initial apnoea-hypopnoea-index 40.7 +/- 22.6/hour) before and after 582 +/- 391 days nCPAP-therapy. Absolute and relative (Broca Index: weight [kg]/[height [cm] -100] x 100) body weight was 97.8 +/- 19.4 kg resp. 128.3 +/- 24.3 units before and 97.3 +/- 18.2 kg resp. 127.8 +/- 23.5 units during therapy (not significant). Body weight changes ranged from +22 to -26 kg. Only a subgroup of patients with a Broca index between 100-119 exhibited a significant weight change from 86.8 +/- 10.4 to 88.5 +/- 10.4 kg. We conclude that our recommendations to lose weight were unsuccessful in patients with obstructive sleep apnoea, although nCPAP-therapy generally improved well-being.

摘要

阻塞性睡眠呼吸暂停综合征的一种简单治疗方法是减轻体重，在开始和维持无创持续气道正压通气（nCPAP）治疗之前，我们一直推荐这一方法。我们记录了123例患者（9名女性，114名男性；年龄53.8±10岁，初始呼吸暂停低通气指数40.7±22.6次/小时）在接受nCPAP治疗582±391天前后的体重。治疗前绝对体重和相对体重（布罗卡指数：体重[kg]/[身高[cm]-100]×100）分别为97.8±19.4 kg和128.3±24.3单位，治疗期间分别为97.3±18.2 kg和127.8±23.5单位（无显著差异）。体重变化范围为+22至-26 kg。只有布罗卡指数在100-119之间的一组患者体重有显著变化，从86.8±10.4 kg变为88.5±10.4 kg。我们得出结论，尽管nCPAP治疗总体上改善了患者的健康状况，但我们关于减肥的建议对阻塞性睡眠呼吸暂停患者并未成功。