Kawamura N, Ito F, Ichimura T, Shibata S, Umesaki N, Ogita S
Department of Obstetrics and Gynecology, Osaka City University Medical School, Japan.
Fertil Steril. 1997 Oct;68(4):632-6. doi: 10.1016/s0015-0282(97)00273-2.
To analyze histopathologic features related to myoma volume reduction after treatment with a GnRH agonist, buserelin acetate, in needle biopsy specimens obtained before treatment.
Prospective clinical study.
University teaching hospital.
PATIENT(S): Twenty women with normal menstrual cycles and symptomatic uterine myomas.
INTERVENTION(S): Buserelin acetate was administered intranasally (900 micrograms/d) for at least 16 weeks; transcervical needle biopsy of the uterine myoma was done before this treatment.
MAIN OUTCOME MEASURE(S): The relation between histopathologic features (degree of cellularity, hyaline change, and collagen content) and the percent decrease in the volume of the largest myoma at 16 weeks measured by magnetic resonance imaging.
RESULT(S): The correlation between the degree of hyaline change and the percent decrease in the myoma volume was significant, as was that with the proportion of collagenous tissue in the specimens.
CONCLUSION(S): We predicted myoma volume reduction after treatment with a GnRH agonist by histologic analysis of the uterine leiomyoma before treatment.
分析在治疗前获取的针吸活检标本中，与醋酸布舍瑞林（一种促性腺激素释放激素激动剂）治疗后肌瘤体积缩小相关的组织病理学特征。
前瞻性临床研究。
大学教学医院。
20名月经周期正常且有症状性子宫肌瘤的女性。
经鼻给予醋酸布舍瑞林（900微克/天）至少16周；在该治疗前对子宫肌瘤进行经宫颈针吸活检。
组织病理学特征（细胞密度、透明样变程度和胶原含量）与通过磁共振成像测量的16周时最大肌瘤体积减少百分比之间的关系。
透明样变程度与肌瘤体积减少百分比之间存在显著相关性，标本中胶原组织比例与肌瘤体积减少百分比之间也存在显著相关性。
我们通过治疗前子宫平滑肌瘤的组织学分析预测了促性腺激素释放激素激动剂治疗后的肌瘤体积缩小情况。
