Ueki M, Okamoto Y, Tsurunaga T, Seiki Y, Ueda M, Sugimoto O
Department of Obstetrics and Gynecology, Osaka Medical College, Japan.
J Obstet Gynaecol (Tokyo 1995). 1995 Feb;21(1):1-7. doi: 10.1111/j.1447-0756.1995.tb00889.x.
The following results were obtained from our investigations performed to compare the effects of danazol (400 mg/day orally for 4 to 6 months, n = 164) with those of buserelin (900 micrograms/day intranasally for 4 to 6 months, n = 83) on patients with uterine myomas. The effectiveness of buserelin (76.1%) in shrinking uterine myomas was better than that of danazol (56.7%). The serum-estradiol and progesterone levels were lower in the buserelin group than in the danazol group. The estrogen and progesterone receptors in a hysterectomied uterus were positively stained even at the end of those therapies. The degree and frequency of hyaline degeneration were higher in the buserelin group than in the danazol group. Thus, the shrinking of uterine myomas and the degree of hyaline degeneration might be caused by the lowering of uterine-tissue hormones, particularly of estradiol levels.
我们进行了调查，比较达那唑（每日口服400毫克，持续4至6个月，n = 164）与布舍瑞林（每日经鼻给予900微克，持续4至6个月，n = 83）对子宫肌瘤患者的影响，得到以下结果。布舍瑞林使子宫肌瘤缩小的有效率（76.1%）高于达那唑（56.7%）。布舍瑞林组的血清雌二醇和孕酮水平低于达那唑组。即使在这些治疗结束时，子宫切除标本中的雌激素和孕激素受体仍呈阳性染色。布舍瑞林组玻璃样变性的程度和发生率高于达那唑组。因此，子宫肌瘤的缩小和玻璃样变性的程度可能是由子宫组织激素水平降低，尤其是雌二醇水平降低引起的。
