Gutiérrez B, Bertranpetit J, Collier D, Arranz M J, Vallès V, Guillamat R, Van Os J, Fañanás L
Unitat d'Antropologia, Facultat de Biologia, Universitat de Barcelona, Spain.
Hum Genet. 1997 Oct;100(5-6):582-4. doi: 10.1007/s004390050556.
Abnormalities of the serotonergic system have classically been associated with the origin of affective disorders through the biochemical action of therapeutic agents and their role in affective and perceptual states. In the present study, we hypothesized that genetic variation in the 5-hydroxytryptamine (serotonin) type 2A (5-HT2A) receptor gene (HTR2A) might have an effect on the aetiology of bipolar affective disorder. Four different polymorphisms in the HTR2A gene were studied in 88 patients with bipolar affective disorder and 113 healthy controls, all of Spanish origin. No significant association was observed between any of the four polymorphisms at the HTR2A locus, whether tested individually or as haplotypes, and bipolar affective disorder. The lack of association suggests that HTR2A is not a major risk factor for bipolar affective disorder.
通过治疗药物的生化作用及其在情感和感知状态中的作用，血清素能系统异常传统上一直与情感障碍的起源相关。在本研究中，我们假设5-羟色胺（血清素）2A型（5-HT2A）受体基因（HTR2A）的基因变异可能对双相情感障碍的病因有影响。我们对88名双相情感障碍患者和113名健康对照者（均为西班牙裔）的HTR2A基因中的四种不同多态性进行了研究。在HTR2A基因座上的四种多态性中的任何一种，无论是单独测试还是作为单倍型进行测试，均未观察到与双相情感障碍有显著关联。缺乏关联表明HTR2A不是双相情感障碍的主要危险因素。
