Sunderji R, Press N, Amin H, Gin K
Vancouver Hospital and Health Sciences Centre, British Columbia.
Can J Cardiol. 1997 Sep;13(9):849-51.
An 81-year-old woman reported with chest pain occurring shortly after initiating treatment with sertraline. She had no prior history of cardiovascular disease. She developed nausea and malaise 4 h after her first dose, which resulted in avoidance of further treatment. After voluntarily reinitiating sertraline 10 days later, she again developed nausea and malaise but persisted with treatment. On the second day, her gastrointestinal symptoms were accompanied by crushing retrosternal chest pain radiating to both arms and resolving spontaneously after 10 mins. Following the third dose of sertraline, the patient experienced severe and persistent crushing retrosternal chest pain radiating to both arms. She was hospitalized with a diagnosis of unstable angina and treated with acetylsalicylic acid, intravenous heparin and nitroglycerin. The temporal relationship of chest pain onset following ingestion of sertraline is strongly suggestive of an adverse medication effect.
一名81岁女性在开始服用舍曲林后不久出现胸痛。她既往无心血管疾病史。首次服药4小时后出现恶心和不适，导致停止进一步治疗。10天后自愿重新开始服用舍曲林，她再次出现恶心和不适，但仍继续治疗。第二天，她的胃肠道症状伴有压榨性胸骨后胸痛，放射至双臂，10分钟后自行缓解。服用第三剂舍曲林后，患者出现严重且持续的压榨性胸骨后胸痛，放射至双臂。她因不稳定型心绞痛入院，接受了阿司匹林、静脉注射肝素和硝酸甘油治疗。舍曲林摄入后胸痛发作的时间关系强烈提示药物不良反应。
